(1) 脂质代谢
(2) 神经-免疫-内分泌代谢

1、科研项目
（1）江苏省科技厅，江苏省自然科学基金青年基金项目，FITM2调控胰岛β细胞胰岛素分泌的作用机制研究，2022-07 至 2025-06，20万元，在研，主持
（2）欧洲研究理事会，ERC advanced grant-LipoCheX，Grant number 340896，The role of lipolysis in the pathogenesis of cancer-associated cachexia，2014-01 至 2019-03，250万 欧元，结题，参与
（3）奥地利科学基金委，SFB Immunometabolism，Grant number F83，Metabolic maintenance of tissue integrity by macrophages，2021-06 至 2025-06，157万+323万 欧元, 在研, 参与
2、代表性科研成果
（1）基于癌症恶液质的病理模型，阐明脂肪组织内免疫-神经-代谢失调打破了组织稳态，引起脂肪组织内β-肾上腺素能信号通路的激活，促进脂解增加和脂肪褐化，出现脂肪异位沉积，诱发并参与恶液质的发生。An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. PNAS, 2022, 119(9): e2112840119.
（2）基于多种原代细胞和肿瘤细胞模型，明确了三酰甘油分解代谢对细胞增殖的抑制作用，增加关键限速酶ATGL的表达/活性升高了脂质氧化作用并抑制肿瘤细胞的增殖。Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling, Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2020, 1865(9):158737.
（3）基于NSCLC模型，阐明ABHD6是肺癌细胞单酰甘油分解代谢的限速酶，明确所有常见癌症亚型通过升高单酰甘油酯酶MAGL或ABHD6的表达/活性促进肿瘤细胞的转移能力和恶性程度。Enhanced monoacylglycerol lipolysis by ABHD6 promotes NSCLC pathogenesis, EBioMedicine, 2020, 53:102696.

1.Xie, H.#; Heier, C.; Meng, X.; Bakiri, L.; Pototschnig, I.; Tang, Z.Y.; Schauer, S.; Baumgartner, V.J.; Grabner, G.F.; Schabbauer, G.; Wolinski, H.; Robertson, G.R.; Hoefler, G.; Zeng, W.W; Wagner, E.F.; Schweiger, M.*; Zechner, R.* An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. PNAS, 2022, 119(9): e2112840119. (IF: 12.779)
2.Gernot, G.#; Xie, H.#; Schweiger, M.*; Zechner, R.*. Lipolysis: Strategies to mobilize fatty acids from cellular lipid stores, Nature Metabolism, 2021, 3, 1445–1465. (IF= 19.950)
3.Tang, Z.Y.#; Xie, H.#; Heier, C.; Huang, J.F.; Zheng, Q.L.; Eichmann, T.O.; Schoiswohl, G.; Ni, J.; Zechner, R.; Ni, S.S.*; Hao, H.P.* Enhanced monoacylglycerol lipolysis by ABHD6 promotes NSCLC pathogenesis, EBioMedicine, 2020, 53:102696. (IF: 8.143)
4.Xie, H.#; Heier, C.; Kien, B.; Vesely, P.W.; Tang, Z.Y.; Sexl, V.; Schoiswohl, G.; Striessnig-Bina, I. ; Hoefler, G.; Zechner, R.*; Schweiger, M.* Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling, Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2020, 1865(9):158737. (IF: 5.228)
5.Zhang, H.W.#; Xie, H.#; Zheng, X.; Chai, Y.Y.; Tang, Z.Y.; Chen, H.Y.; Li, F.Y.; Christoph, H.; Chen, J.D.; Sun, W.X.; Ye, H.; Wang, S.G.; Hao, H.P.*; Chen, X.H.* Salicylic acid retention impairs aspirin reactivity in type 2 diabetes, European Journal of Pharmacology, 2017, 794. (IF: 5.195)
6.Xie, H.#; Sun, S.Q.; Cheng, X.F.; Yan, T.T.; Zheng, X.; Li, F.Y.; Qi, Q.; Wang, G.J.*; Hao, H.P. Dysregulations of intestinal and colonic UDP-glucuronosyltransferases in rats with type 2 diabetes, Drug Metabolism and Pharmacokinetics. 2013, 28.5. (IF: 2.041)
7.Heier, C.#; Knittelfelder, O.; Hofbauer, H.F.; Mende, W.; Pornbacher, I.; Schiller, L.; Schoiswohl, G.; Xie, H.; Gronke, S.; Shevchenko, A.; Kuhnlein, R.P. Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success, Elife. 2021, Feb 4;10:e63252. (IF: 8.713)
8.Schreiber, R.*; Xie, H.; Schweiger, M.* Of mice and men: The physiological role of adipose triglyceride lipase (ATGL), Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2018, 1864(6), 880-899. (IF:5.228)
9.Heier, C.#; Kien, B.; Huang, F.F.; Eichmann, T.O.; Xie, H.; Zechner, R.; Chang, P.A.* The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain, Journal of Biological Chemistry. 2017, 292(46): 19087-19098. (IF:5.486)
10.Tang, Z.Y.#; Shen, Q.; Xie, H.; Zhou, Z.; Shi, G.; Zhang, C.; Mohammed, A.; Wu, Y.; Ni, S.S.; Zhou, X.Y. Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and γ-ray irradiation was elucidated, Oncology reports. 2018, 39(3): 1505-1515. (IF: 4.136)

博士研究生
王顺 （2022级）
硕士研究生
孙新沅 （2022级）