1、教育经历
(1) 2012/09-2017/07, 学院, 药物分析学, 博士
(2) 2008/09-2012/07, 学院, 制药工程, 学士
2、工作经历
(1) 2022/07-至今, 学院, 澳门十大老牌信誉平台排行榜, 副研究员
(2) 2020/07-2022/07, 学院, 澳门十大老牌信誉平台排行榜, 讲师
(3) 2017/07-2020/07, 学院, 中澳门十大老牌信誉平台排行榜, 博士后
(1) 药物质量研究与安全性评价
(2) 基于金属组学的药物作用机制研究
1、科研项目
(1)国家自然科学基金青年基金项目,81903911,基于汞元素金属组学的朱砂中枢神经毒性机制研究,2020-01-01 至 2022-12-31,21万元,在研,主持
(2)江苏省自然科学基金青年项目,BK20190556,基于金属组学的朱砂中枢神经毒性研究,2019-07 至 2022-06,20万元,已结题,主持
(3)中国博士后科学基金面上资助,2017M621885,含朱砂中成药柏子养心丸基于汞形态的毒性与安全性研究,2017-09至2020-06,5万元,已结题,主持
2、代表性科研成果
(1)微量杂质分析是药物质量控制的重点与难点之一,基于高分辨质谱等现代分析技术,摸索并形成了成熟的药物杂质研究策略,现已成功帮助企业完成氟马西尼、佐匹克隆等多个药物品种原料药及制剂的生产工艺优化与质量提升。
(2)针对传统中药朱砂(HgS)的安全性与质量问题,基于金属组学研究,探索其物质基础、作用机制及药物相互作用。首次发现朱砂在生物体内的汞元素形态转化,明确了其物质基础;并将汞元素形态引入到含朱砂中药的质量控制之中,确立了与朱砂相关的关键制剂质量控制点,为朱砂及含朱砂制剂的质量控制和合理使用提供宝贵的参考依据。
1.Jiang, J.; Hu, Z.L.; Boucetta, H.; Liu, J.M.; Song, M.; Hang, T.J.*; Lu, Y.T.* Identification of degradation products in flumazenil using LC-Q-TOF/MS and NMR: Degradation pathway elucidation. J. Pharm. Biomed. Anal. 2022, 12;215:114764. (IF: 3.571)
2.Xu, L.; Wang, Y.; Wu, D.F.; Sun, F.M.; Di, B.; Xu, H.; Song, M.; Lu, Y.T.*; Hang, T.J.* Identification and monitoring of fentanyls-related substances in east China sewage water samples by LC-MS for drug enforcement. Sci Total Environ. 2021, 797:149109. (IF:7.963)
3.Han, X.; Cheng, F.J.; Di, B.; Xu, H.; Song, M.; Hang, T.J.*; Lu, Y.T.* Identification and characterization of new impurities in zopiclone tablets by LC-QTOF-MS. J. Pharm. Biomed. Anal. 2021, 199:114056. (IF: 3.935)
4.Lu, Y.T.; Hu, Z.L.; Shao, F.X.; Song, M. Hang, T.J.* Simultaneous determination of tazarotene, clindamycin phosphate and their active metabolites in Bama mini-pig skin by LC-MS/MS: Application to the development of a tazarotene/clindamycin phosphate cream techniques. J. Chromatogr. B 2021, 1162:122455. (IF: 3.205)
5.Lu, Y.T.; Guan, R.; Zheng, J.R.; Hang, T.J.*; Song, M.* Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies. J. Pharm. Biomed. Anal. 2020, 186, 113322. (IF: 3.209)
6.Lu, Y.T.; Qi, W.Z.; Wang, S.; Song, X.N.; Yang, D.Y.; Song, M.; Hang, T.J.* Toxicity and risk assessment of mercury exposures from cinnabar and Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies. J Ethnopharmacol. 2020, 250, 112489. (IF: 4.360)
7.Lu, Y.T.; Chen, Y.F.; Qi, W.Z.; Song, M.*; Hang, T.J.* Separation and identification of process-related substances and degradation products in mycophenolate mofetil by LC-QTOF mass spectrometric method. J. Sep. Sci. 2019, 42(16):2650-2659. (IF: 2.878)
8.Lu, Y.T.; Sun, X.Y.; Song, F.; Wang, L.; Song, M.; Hang, T.J.* Impurity profiling of varenicline tartrate by LC-QTOF mass spectrometric techniques during drug development. J. Pharm. Biomed. Anal. 2018, 155: 306-313. (IF: 2.983)
9.Lu, Y.T.; Yang, D.Y.; Song, X.N.; Wang, S.; Song, M.; Hang, T.J.* Bioaccessibility and health risk assessment of mercury in cinnabar containing Traditional Chinese Medicines. J. Trace Elem. Med. Bio. 2017, 44: 17-25. (IF: 3.755)