1.心血管疾病创新药物的发现。
2.精神疾病创新药物的发现。
3.药用天然产物结构优化、全合成以及成药性评价研究。
4.药物合成工艺研究。

​主持完成国家自然科学基金面上项目、江苏省自然科学基金面上项目、教育部科学技术研究重点项目、江苏省重点研发计划、南京市领军型科技创业人才引进计划项目、江苏省博士后资助计划、江苏省青蓝工程优秀骨干教师培育项目等多项，目前主持国家自然科学基金面上项目、江苏省自然科学基金面上项目、学院“双一流”新药品种研发项目以及江苏省研究生创新培养计划、国家大学生创新实践项目及企业合作课题等。同时指导完成了先声药业研究生创新基金、华海药业研究生创新基金、江苏省研究生创新培养计划、国家大学生创新实践项目、开放性实验项目等多项。参加国家自然科学基金面上项目、国家自然科学基金重点项目、江苏省杰出青年基金和科技部863计划项目等多项。作为课题主要完成人，获得2016年国家科技进步二等奖，获得2015年教育部自然科技进步一等奖、江苏省自然科技进步一等奖。

1.Zhuoer Zhi#, Wenting Zhang#, Jingchun Yao, Yanguo Shang, Qingjing Hao, Zhong Liu, Yushan Ren, Jie Li, Guimin Zhang*, Jinxin Wang*, Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors. J. Med. Chem. 2020, 63, 5783-5796.
2.Kan Yang#, Jinying Yu#, Keyi Nong, Youzhi Wang, Ao Niu, Wenlu Chen, Jibin Dong*, Jinxin Wang*, Discovery of potent, selective, and direct acid sphingomyelinase inhibitors with antidepressant activity, J. Med. Chem. 2020, 63, 961-974.
3.Yanguo Shang, Qingjing Hao, Kaixuan Jiang, Mengting He, Jinxin Wang*, Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation. Bioorg Med Chem Lett 2020, 30 (10), 127118.
4.Minghui Wang, Ao Niu, Zhibo Gong, Zhengwen Xu, Lili Li, Bo Li, Jinxin Wang*, PEG-amino acid-przewaquinone a conjugations: Synthesis, physicochemical properties and protective effect in a rat model of brain ischemia-reperfusion. Bioorg Med Chem Lett 2020, 30 (1), 126780.
5.Kan Yang, Kaixuan Jiang, Zhengwen Xu, Yali Song, Jinxin Wang*，Targeting sphingosine kinase 1 for the treatment of pulmonary arterial hypertension，Future Med. Chem. 2019, 11(22): 2939-2953.
6.Kan Yang, Keyi Nong, Qinlan Gu, Jibin Dong, Jinxin Wang*, Discovery of N-hydroxy-3-alkoxybenzamides as direct acid sphingomyelinase inhibitors using a ligand-based pharmacophore model, Eur. J. Med. Chem., 2018, 151:389-400.
7.Kan Yang, Biao Gao, Xianjun Ming, Zhipeng Huang, Minghui Wang, Jibin Dong*, Jinxin Wang*，Design, synthesis, biological evaluation and QSAR analysis of 1, 3, 6, 7, 8-substituted xanthones as novel acid sphingomyelinase inhibitors: potential treatment for ultraviolet-induced skin damage, Future Med. Chem. 2017, 9(16):1887-1898.
8.Xiaoling Bi, Kuojun Zhang, Long He, Biao Gao, Qinlan Gu, Xueyan Li, Jun Chen, Jinxin Wang*, Synthesis and biological evaluation of tanshinone IIA derivatives as novel endothelial protective agents. Future Med. Chem. 2017, 9 (10), 1073-1085.
9.Kaili Chen, Biao Gao, Yanguo Shang, Jianyao Du, Qinlan Gu, Jinxin Wang*, I2-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones. Org. Biomol. Chem. 2017, 15 (41), 8770-8779.
10. Biao G aili Chen, Xiaoling Bi, Jinxin Wang*, Intramolecular functionalization of C(sp 3 ) H bonds adjacent to an amide nitrogen atom: Metal-free synthesis of 2-hydroxy-benzoxazinone derivatives. Tetrahedron 2017, 73 (50), 7005-7010.