• 郭小可

    药物化学系 副教授
    领域:生物活性分子设计与合成及成药性评价
    联系电话:
    电子邮箱:kexin95@126.com
    办公室:江宁校区学院实验楼513室
    实验室:江宁校区学院实验楼525
  • 1、教育经历
    (1) 2009/09-2014/06, 学院,药物化学专业, 博士
    (2) 2005/09-2009/07, 学院,基础药学理科基地班,学士
    2、工作经历
    (1) 2017/07 至今, 学院,澳门十大老牌信誉平台排行榜,副教授
    (2) 2014/06-2017/06, 学院,澳门十大老牌信誉平台排行榜,讲师
    3、学术荣誉
    2022/05,江苏高校“青蓝工程”优秀骨干教师
    2021/03,江苏省青年岗位能手
    2020/08,江苏省五一创新能手
    2020/08,江苏省技术能手
    4、学术兼职
    2022/06,药学与临床研究杂志青年编委
    (1)表观遗传修饰酶相关调控剂的设计与合成
    (2)抗肿瘤小分子化合物的合成与成药性评价
    (1)国家自然科学基金委员会,面上项目,82173673,基于靶标结构设计、合成高选择性ALKBH5抑制剂并探索其在肿瘤疾病中的应用,2022-01-01 至 2025-12-31,55万元,在研,主持
    (2)国家自然科学基金委员会,面上项目,81872799,通过构象调控方法设计MLL1-WDR5蛋白-蛋白相互作用小分子抑制剂并探索其在血液肿瘤中的应用,2019-01-01 至 2022-12-31,57万元,在研,主持
    (3)国家自然科学基金委员会,青年基金,81502915 全新骨架组蛋白甲基转移酶G9a抑制剂的构效关系、结合模式及作用机制研究,2015-01-01 至 2018-12-31,21.28万元,结题,主持
    (4)江苏省自然科学基金委员会,面上项目,BK20191321,新型靶向MLL1-WDR5治疗血液肿瘤的小分子抑制剂的设计、合成及生物学研究,2019-07-01 至 2022-06-31,10万元,在研,主持
    1.Lingyue Zhao, Qian Yang , Yiqun Tang, Qidong You* and Xiaoke Guo*, Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors, J. Enzym. Inhib. Med. Chem. 2022, 37(1), 462-471. (IF = 5.756)
    2.Weilin Chen, Xin Chen, Dongdong Li, Jianrui Zhou, Zhengyu Jiang*, Qidong You* and Xiaoke Guo*, Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5–Mixed Lineage Leukemia 1 Protein–Protein Interaction for the Treatment of MLL Fusion Leukemia, J. Med. Chem. 2021, 64(12), 8221-8245. (IF = 8.039)
    3.Xin Chen, Junjie Xu, Xianghan Wang, Guanlu Long, Qidong You* and Xiaoke Guo*, Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective, J. Med. Chem. 2021, 64(15), 10537-10556. (IF = 8.039)
    4.Weilin Chen, Xin Chen, Dongdong Li, Xianghan Wang, Zhengyu Jiang*, Qidong You* and Xiaoke Guo*, Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity, Eur. J. Med. Chem., 2021, 223, 113677. (IF = 7.088)
    5.Wei-Lin Chen, Dong-Dong, Xin Chen, Ying-Zhe Wang, Jun-Jie Xu, Zheng-Yu Jiang*, Qi-Dong You*, Xiao-Ke Guo*, Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction, Eur. J. Med. Chem., 2020, 188, 112027. (IF = 7.088)
    6.Jing Gu, Jun Xu, Qi-Dong You*, Xiao-Ke Guo*, Recent developments of small molecules targeting RNA m6A, Eur. J. Med. Chem., 2020, 196, 112325. (IF = 7.088)
    7.Wei-Lin Chen, Dong-Dong Li, Zhi-Hui Wang, Xiao-Li Xu, Xiao-Jin Zhang, Zheng-Yu Jiang, Xiao-Ke Guo*, Qi-Dong You*, Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5, Bioorg. Chem., 2017, 76, 380-385. (IF = 5.307)
    8.Wei-Lin Chen, Zhi-Hui Wang, Tao-Tao Feng, Dong-Dong Li, Chu-Hui Wang, Xiao-Li Xu, Xiao-Jin Zhang, Qi-Dong You*, Xiao-Ke Guo*, Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification, Bioorg. Med. Chem., 2016, 24, 6102-6108. (IF = 3.461)
    9.Dong-Dong Li, Wei-Lin Chen, Zhi-Hui Wang, Yi-Yue Xie, Xiao-Li Xu, Zheng-Yu Jiang, Xiao-Jin Zhang, Qi-Dong You*, Xiao-Ke Guo*, High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity, Eur. J. Med. Chem., 2016, 124, 480-489. (IF = 7.088)
    10.Tao-Tao Feng, Dong-Dong Li, Hai Wang, Jian Zhuang, Fang Liu, Qichao Bao, Yonghua Lei, Wei-Lin Chen, Xiao-Jin Zhan, Xiao-Li Xu, Hao-Peng Sun, Qi-Dong You*, Xiao-Ke Guo*, Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: Introduction of an additional carboxyl group at the C-2 position of quinoline, Eur. J. Med. Chem., 2015, 105, 145-155. (IF = 7.088)
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