通知公告

学院青年学者联合会第四十四期学术报告通知

发布时间:2022-03-07浏览次数:2822

报告时间2022314日周一下午14:00-16:00

报告形式线下、线上结合报告

主 持 人:肖易倍 教授

讲 座 人:肖兰博 博士

线下地点:学院 学院实验楼 122会议室

线上地址:腾讯会议 648 797 681

报告题目:Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

Abstract: The SWI/SNF complex has a crucial role in chromatin remodelingand is altered in over 20% of cancers. Here we developed a PROTAC degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4, called AU-15330. AR positive prostate cancer cells are exquisitely sensitive to dual SMARCA2 and SMARCA4 degradation relative to normal and other cancer cell lines. SWI/SNF ATPase degradation rapidly compacts cis-regulatory elements bound by transcription factors that drive prostate cancer cell proliferation, namely AR, FOXA1, ERG and MYC, which dislodges them from chromatin, disables their core enhancer circuitry, and abolishes the downstream oncogenic gene programs. SWI/SNF ATPase degradation also disrupts super-enhancer and promoter looping interactions that wire supra-physiologic expression of the AR, FOXA1 and MYC oncogenes themselves. Thus, impeding SWI/SNF-mediated enhancer accessibility represents a promising therapeutic approach for enhancer-addicted cancers.

 

个人简介:

   肖兰博,密歇根大学医学院病理系Research Investigator2004-2008年湖南农业大学生物技术系本科,2008-2014年中南大学湘雅医学院肿瘤研究所基础医学博士(导师:曹亚教授、孙仑泉教授)。20142018,在美国密歇根大学医学院Arul M. Chinnaiyan教授领导的密歇根大学转化病理学中心完成了博士后训练。2018年至今,继续在密歇根大学转化病理学中心从事前列腺癌及其他恶性肿瘤的基础及转化研究。主要研究方向为肿瘤表观遗传学和肿瘤药理学,首次明确了SWI/SNF染色质重塑复合物的ATPase是一个潜在的前列腺癌靶向治疗关键靶点。在国际知名学术期刊发表研究论文共35篇,其中包括NatureCancer ResOncogene一作各一篇。以PIco-PI身份主持Prostate Cancer Research Program Early Investigator Research Award Idea Development AwardProstate Cancer Foundation Challenge Award各一项。


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                  学院青年学者联合会

 

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